Rapid, animal-free discovery of single-domain antibodies from a novel synthetic library

Single-domain antibodies (sdAbs), also known as nanobodies or VHH, are the smallest functional antibody fragments known in nature and have risen to prominence in recent years for being able to bind a wide range of targets with applications spanning immunoassays, diagnostics, and therapeutics. We have developed a fully synthetic, high diversity sdAb library with an estimated 1012 total members, and have paired this library with a novel, AI-enabled approach to library screening for rapid antibody discovery. Finally, we developed an agglutination-based sensor platform (the ImmunoQube™) that integrates newly discovered nanobodies into an automated instrument for multiplexed, at-line protein quantification. Together, these tools enable customized nanobodies and sensing solutions for a wide range of applications.

For more information, check out our recent poster.